Infection Biology
A trainee is asked about biofilm formation during a basic science viva. The examiner presents a case of a patient with prosthetic joint infection who failed multiple courses of antibiotics despite culture-proven sensitivity. The trainee is asked to explain the mechanisms underlying antibiotic failure in implant-associated infections. Regarding biofilm formation and its clinical implications:
Mark each as TRUE or FALSE
Biofilm is a structured bacterial community enclosed in self-produced extracellular polymeric substa...
Biofilm formation occurs in stages: reversible attachment (0-4 hours), irreversible attachment with ...
Biofilm bacteria are genetically resistant to antibiotics which explains their increased MIC; persis...
Persister cells are dormant, metabolically inactive bacteria (0.1-1% of biofilm population) that sur...
DAIR (debridement, antibiotics, implant retention) is only successful for acute infections (less tha...
Answer the questions to see explanations
Click T (True) or F (False) for each option