Metabolic Bone Disease
A 72-year-old woman presents after a low-energy hip fracture. She has a history of vertebral compression fractures and is on long-term bisphosphonate therapy. Laboratory workup shows low vitamin D levels and mildly elevated PTH. Her DEXA scan from last year showed a T-score of -3.2 at the femoral neck. She asks about the mechanisms of osteoporosis and available treatments. Regarding bone metabolism and calcium homeostasis:
Mark each as TRUE or FALSE
Calcium homeostasis is maintained by the interplay of parathyroid hormone (PTH), vitamin D, and calc...
Bone remodeling involves the coordinated action of osteoclasts (bone resorption) and osteoblasts (bo...
PTH decreases serum calcium; calcitonin is the primary regulator of calcium homeostasis; vitamin D i...
Bisphosphonates (alendronate, zoledronic acid) are first-line anti-resorptive agents that bind to hy...
Denosumab is a RANKL inhibitor (monoclonal antibody) that prevents osteoclast formation and activity...
Answer the questions to see explanations
Click T (True) or F (False) for each option