Bone Biology
A 70-year-old woman with osteoporosis is being counselled about bone biology before starting anti-resorptive therapy. She asks about how her bones are maintained and how medications work to strengthen them. Her DEXA scan shows T-scores of -2.8 at the lumbar spine and -2.5 at the femoral neck. She had a low-trauma wrist fracture 6 months ago. Regarding bone metabolism and remodelling:
Mark each as TRUE or FALSE
Bone remodelling is a continuous process where osteoclasts resorb old bone followed by osteoblasts f...
Osteoclasts are derived from haematopoietic monocyte-macrophage lineage; they require RANKL (from os...
Osteoclasts are derived from mesenchymal stem cells; osteoblasts resorb bone; OPG stimulates osteocl...
Osteoblasts are derived from mesenchymal stem cells and produce Type I collagen (90% of organic matr...
Bisphosphonates bind hydroxyapatite and are taken up by osteoclasts, inducing apoptosis (nitrogen-co...
Answer the questions to see explanations
Click T (True) or F (False) for each option