Growth Factors
A 52-year-old man is undergoing anterior lumbar interbody fusion (ALIF) at L4/5. The surgeon plans to use recombinant human BMP-2 (rhBMP-2) in a collagen sponge carrier within a PEEK cage. He has a history of previous malignancy (prostate cancer in remission for 5 years) and asks about the biology and safety of BMPs. Regarding bone morphogenetic proteins:
Mark each as TRUE or FALSE
BMPs are members of the TGF-beta superfamily and are osteoinductive (can induce bone formation in no...
BMP-2 is FDA-approved for open tibial fractures (with IM nail), single-level ALIF, and sinus augment...
BMPs are osteoconductive rather than osteoinductive; they require existing bone surfaces to work; BM...
Significant complications of BMP-2 include heterotopic ossification, osteolysis, seroma formation, a...
BMP antagonists (noggin, chordin, follistatin) regulate BMP activity by preventing receptor binding;...
Answer the questions to see explanations
Click T (True) or F (False) for each option