Bone Biology
A 65-year-old postmenopausal woman is being evaluated for osteoporosis management. Her DEXA scan shows a T-score of -2.8 at the lumbar spine. She has no secondary causes of bone loss. The endocrinologist is discussing treatment options including bisphosphonates and anabolic agents, explaining how they target different aspects of the bone remodeling cycle. Regarding bone remodeling and coupling:
Mark each as TRUE or FALSE
Bone remodeling is the continuous process of bone resorption and formation occurring in discrete uni...
Coupling refers to the coordinated link between resorption and formation ensuring bone balance; oste...
Bone remodeling occurs continuously without discrete units; osteoclasts and osteoblasts act simultan...
The RANK/RANKL/OPG system is central to osteoclast regulation: RANKL (produced by osteoblasts and os...
Osteocytes are the master regulators of remodeling: they sense mechanical loading and microdamage, p...
Answer the questions to see explanations
Click T (True) or F (False) for each option