Bone Biology
A 68-year-old postmenopausal woman is being counseled about osteoporosis treatment options. She asks about how her bones naturally turn over and how the medications work. Her recent DXA scan shows a T-score of -2.8 at the lumbar spine. She is being started on a bisphosphonate. Regarding the bone remodeling cycle:
Mark each as TRUE or FALSE
Bone remodeling is a continuous process replacing old or damaged bone with new bone; the cycle invol...
Osteoclasts are multinucleated cells derived from monocyte-macrophage lineage that resorb bone throu...
Osteoclasts are derived from mesenchymal stem cells; osteoblasts come from hematopoietic lineage; bo...
The RANK/RANKL/OPG system regulates osteoclastogenesis: RANKL (produced by osteoblasts and osteocyte...
Bisphosphonates are incorporated into bone matrix and taken up by osteoclasts during resorption, ind...
Answer the questions to see explanations
Click T (True) or F (False) for each option