Bone Biology
A trainee is preparing for a basic science viva on bone biology. The examiner asks about the mechanisms by which bone adapts to mechanical loading and the therapeutic implications of targeting these pathways for osteoporosis treatment. Regarding mechanical regulation of bone remodeling:
Mark each as TRUE or FALSE
Wolff's Law states that bone adapts its structure to the mechanical loads placed upon it; osteocytes...
Sclerostin is a glycoprotein encoded by the SOST gene, produced primarily by osteocytes; it inhibits...
Sclerostin is produced by osteoclasts and stimulates bone resorption; high sclerostin levels increas...
Romosozumab is a humanized monoclonal anti-sclerostin antibody used to treat osteoporosis; it mimics...
The Wnt/beta-catenin pathway is a critical regulator of bone mass; Wnt ligands bind Frizzled/LRP5/6 ...
Answer the questions to see explanations
Click T (True) or F (False) for each option