Musculoskeletal Biology
A 28-year-old soccer player has a 2 cm focal cartilage defect of the medial femoral condyle discovered during arthroscopy for meniscal repair. The defect extends to subchondral bone. The patient wishes to return to high-level sport. You are discussing cartilage repair options. Regarding articular cartilage biology and repair:
Mark each as TRUE or FALSE
Hyaline articular cartilage is composed of chondrocytes (1-5% volume) within an extracellular matrix...
Cartilage has four distinct zones: superficial/tangential (flattened chondrocytes, collagen parallel...
Cartilage is highly vascular and receives direct blood supply; Type I collagen is the predominant co...
Marrow stimulation techniques (microfracture, drilling) penetrate subchondral bone to allow mesenchy...
Cell-based techniques include autologous chondrocyte implantation (ACI - harvest, culture, reimplant...
Answer the questions to see explanations
Click T (True) or F (False) for each option