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Basic Science
intermediate
X-Type

Clinical Practice Guidelines and Evidence-Based Medicine

Research and Statistics

A junior surgeon asks about the Australian Orthopaedic Association (AOA) guidelines for VTE prophylaxis in total hip arthroplasty. You explain that clinical practice guidelines are systematically developed statements to assist practitioner and patient decisions about appropriate healthcare for specific clinical circumstances. Understanding how guidelines are developed, appraised, and implemented is essential for evidence-based practice. You mention that the GRADE (Grading of Recommendations Assessment, Development and Evaluation) framework is widely used to assess evidence quality and make recommendations. Regarding clinical practice guidelines and evidence-based medicine:

Mark each as TRUE or FALSE

A

The GRADE system separates the quality of evidence (high, moderate, low, very low) from the strength...

B

The AGREE II (Appraisal of Guidelines for Research and Evaluation) instrument assesses guideline qua...

C

Strong recommendations in GRADE indicate "DO" or "DO NOT DO" statements where benefits clearly outwe...

D

Implementation of clinical practice guidelines faces the "4 As" barriers: Awareness (clinicians unaw...

E

The hierarchy of evidence in traditional evidence-based medicine places systematic reviews/meta-anal...

Answer the questions to see explanations

Click T (True) or F (False) for each option