Connective Tissue Biology
A medical student presents a case of osteogenesis imperfecta during a musculoskeletal pathology seminar. The discussion turns to normal collagen structure and function. The biochemist explains the importance of the triple helix structure, the role of glycine at every third position, post-translational hydroxylation requiring vitamin C, and the specific collagen types found in different musculoskeletal tissues. The student asks which collagen types are most relevant to orthopaedic practice. Regarding collagen structure and types:
Mark each as TRUE or FALSE
Collagen has a characteristic TRIPLE HELIX structure with three polypeptide ALPHA CHAINS coiled toge...
Post-translational modification includes HYDROXYLATION of proline and lysine residues (forming HYDRO...
Collagen has a SINGLE HELIX structure; ALANINE is required at every third position; vitamin K is req...
TYPE I COLLAGEN is the most abundant collagen in the body (90%) and is found in BONE, TENDON, LIGAME...
Collagen disorders include OSTEOGENESIS IMPERFECTA (Type I collagen mutation causing brittle bones),...
Answer the questions to see explanations
Click T (True) or F (False) for each option