Bone Biology
A researcher is investigating the molecular mechanisms of fracture healing. They observe different growth factors being expressed at various stages of the healing process. Early in the inflammatory phase, certain factors are released from platelets and inflammatory cells, while during the reparative phase, different factors drive mesenchymal stem cell differentiation and bone formation. Regarding growth factors in bone healing:
Mark each as TRUE or FALSE
Bone Morphogenetic Proteins (BMPs), particularly BMP-2 and BMP-7 (OP-1), are members of the TGF-beta...
Platelet-Derived Growth Factor (PDGF) is released early in fracture healing from alpha-granules of p...
TGF-beta inhibits bone formation and is detrimental to fracture healing; VEGF has no role in bone he...
Transforming Growth Factor-beta (TGF-beta) stimulates mesenchymal stem cell proliferation and extrac...
Vascular Endothelial Growth Factor (VEGF) is critical for angiogenesis during fracture healing and i...
Answer the questions to see explanations
Click T (True) or F (False) for each option