Molecular Signaling
A basic science researcher is presenting at an orthopaedic conference about molecular signaling pathways in skeletal development. The discussion focuses on the Hedgehog signaling pathway and its role in limb patterning, chondrocyte differentiation, and bone formation. A registrar asks about the clinical relevance of this pathway in congenital limb anomalies and potential therapeutic targets. Regarding the Hedgehog signaling pathway in orthopaedics:
Mark each as TRUE or FALSE
The Hedgehog (Hh) family includes Sonic hedgehog (Shh), Indian hedgehog (Ihh), and Desert hedgehog (...
Hedgehog signaling involves the transmembrane receptor Patched (Ptch) and the signal transducer Smoo...
Hedgehog signaling is unimportant in skeletal development; Shh inhibits limb patterning; Ihh has no ...
Clinical relevance: Shh abnormalities can cause limb malformations including preaxial polydactyly (d...
Indian hedgehog (Ihh) coordinates with PTHrP in a negative feedback loop: Ihh from prehypertrophic c...
Answer the questions to see explanations
Click T (True) or F (False) for each option