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Basic Science
intermediate
X-Type

Nerve Regeneration Principles

Neurophysiology

A 32-year-old man sustains a laceration to his forearm during a workplace accident. He has complete loss of sensation in the median nerve distribution and inability to oppose the thumb. Exploration reveals the median nerve is in continuity but with significant bruising. EMG at 3 weeks shows no voluntary motor unit potentials but preserved sensory nerve action potentials proximal to the injury. Tinel's sign is present at the injury site. Regarding peripheral nerve injury and regeneration:

Mark each as TRUE or FALSE

A

The Seddon classification includes: neurapraxia (conduction block, intact endoneurium, complete reco...

B

The Sunderland classification expands on Seddon: Type 1 (neurapraxia), Type 2 (axonotmesis), Type 3 ...

C

Wallerian degeneration occurs proximal to injury; neurapraxia involves axon loss; neurotmesis recove...

D

Wallerian degeneration occurs distal to the injury site: axon and myelin breakdown, Schwann cells pr...

E

Factors affecting recovery include: age (younger better), injury level (proximal worse), delay to re...

Answer the questions to see explanations

Click T (True) or F (False) for each option