Molecular Biology
A researcher is investigating signaling pathways that regulate bone cell differentiation. They are studying the Notch pathway, which involves transmembrane receptors that are cleaved upon ligand binding to release an intracellular domain that translocates to the nucleus. Regarding Notch signaling in bone:
Mark each as TRUE or FALSE
Notch signaling is a highly conserved cell-cell communication pathway involving transmembrane recept...
In bone, Notch signaling generally suppresses osteoblast differentiation and maintains mesenchymal p...
Notch signaling promotes osteoblast differentiation; it enhances osteoclast formation; NICD remains ...
Hajdu-Cheney syndrome is caused by NOTCH2 mutations that prevent degradation of NICD, leading to sus...
Notch signaling interacts with other bone pathways including Wnt, BMP, and PTH signaling; gamma-secr...
Answer the questions to see explanations
Click T (True) or F (False) for each option