Bone Formation
A 3-year-old child presents with frontal bossing and a widened anterior fontanelle. Skull radiographs show poorly mineralized calvarial bones with wormian bones. Genetic testing confirms a diagnosis of cleidocranial dysplasia with RUNX2 mutation. Regarding intramembranous ossification and its disorders:
Mark each as TRUE or FALSE
Intramembranous ossification occurs directly from mesenchymal condensation without a cartilage inter...
RUNX2 (Cbfa1) is the master transcription factor for osteoblast differentiation; mutations cause cle...
Intramembranous ossification requires a hyaline cartilage template; the clavicle forms entirely thro...
During intramembranous ossification, mesenchymal cells aggregate at ossification centres, differenti...
The clavicle is unique as it forms by both intramembranous (medial aspect) and endochondral (lateral...
Answer the questions to see explanations
Click T (True) or F (False) for each option