Osteoblast Biology
A 65-year-old postmenopausal woman with osteoporosis is being treated with romosozumab, a monoclonal antibody against sclerostin. After 12 months, her bone mineral density has increased by 13% at the lumbar spine. Regarding osteoblast biology and Wnt signaling:
Mark each as TRUE or FALSE
Osteoblasts derive from mesenchymal stem cells through a differentiation pathway requiring sequentia...
The canonical Wnt/β-catenin pathway is the major anabolic signaling pathway in bone; Wnt ligands bin...
Sclerostin is produced by osteoblasts and activates Wnt signaling; romosozumab works by enhancing sc...
Sclerostin (SOST gene product) is secreted by osteocytes and inhibits Wnt signaling by binding to LR...
High bone mass disorders from Wnt pathway activation include: LRP5 gain-of-function mutations, scler...
Answer the questions to see explanations
Click T (True) or F (False) for each option