Bone Cell Biology
A medical student is studying bone biology and asks about the mechanism of bone resorption. The consultant explains that osteoclasts are specialized cells derived from the monocyte-macrophage lineage that are responsible for bone resorption. Understanding osteoclast biology is essential for understanding conditions like osteoporosis and the mechanism of drugs like denosumab and bisphosphonates. Regarding osteoclast activation and function:
Mark each as TRUE or FALSE
Osteoclasts are multinucleated giant cells derived from monocyte-macrophage precursors; they are for...
The mature osteoclast attaches to bone via the sealing zone which creates an isolated resorption com...
Osteoclasts are derived from osteoblast precursors; they are mononuclear cells; RANKL inhibits osteo...
OPG (osteoprotegerin) is a decoy receptor secreted by osteoblasts that binds RANKL and prevents it f...
Therapeutic targeting of osteoclasts includes bisphosphonates which are incorporated into bone matri...
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Click T (True) or F (False) for each option