Bone Biology and Metabolism
A 72-year-old postmenopausal woman with osteoporosis (T-score -3.2) is being counselled about treatment options. She has sustained a Colles' fracture after a fall from standing height. Her medical history includes gastro-oesophageal reflux disease. The orthopaedic surgeon discusses the mechanisms of bone resorption and available therapies targeting this pathway. Regarding osteoclast biology and the RANK/RANKL/OPG pathway:
Mark each as TRUE or FALSE
Osteoclasts are derived from HAEMATOPOIETIC stem cells of the monocyte/macrophage lineage; they are ...
The RUFFLED BORDER is the resorptive surface with deep membrane foldings; the SEALING ZONE (clear zo...
Osteoclasts are derived from MESENCHYMAL stem cells like osteoblasts; they are MONONUCLEAR cells; th...
RANKL (Receptor Activator of Nuclear factor Kappa-B Ligand) is produced by OSTEOBLASTS and OSTEOCYTE...
M-CSF (Macrophage Colony-Stimulating Factor) is also required for osteoclast differentiation (binds ...
Answer the questions to see explanations
Click T (True) or F (False) for each option