Bone Biology
A research fellow presents on the cellular mechanisms underlying Wolff's Law during a journal club session. She discusses how bone adapts to mechanical loading through the osteocyte network, explaining the role of the lacunar-canalicular system in mechanosensing. The discussion extends to sclerostin, its inhibitory effects on bone formation, and the clinical implications for anti-osteoporosis therapies. An attending asks about the signaling pathways involved in mechanotransduction. Regarding osteocyte function and mechanotransduction:
Mark each as TRUE or FALSE
OSTEOCYTES are the most abundant bone cells (90-95%), derived from osteoblasts that become embedded ...
MECHANOTRANSDUCTION occurs via fluid flow through the LACUNAR-CANALICULAR SYSTEM; mechanical loading...
Osteocytes are the LEAST abundant bone cells (5%); they are derived from osteoclasts; they are locat...
SCLEROSTIN (SOST gene product) is produced by osteocytes and INHIBITS WNT signaling at the LRP5/6 co...
Osteocyte APOPTOSIS releases signals that recruit osteoclasts for TARGETED REMODELING; osteocytes re...
Answer the questions to see explanations
Click T (True) or F (False) for each option