Joint Physiology
A medical student asks about the basic science behind viscosupplementation for knee osteoarthritis. The orthopaedic registrar explains the physiology of synovial fluid and lubrication. Regarding synovial fluid and joint lubrication:
Mark each as TRUE or FALSE
Synovial fluid is an ultrafiltrate of plasma with added hyaluronic acid (hyaluronan) secreted by typ...
Hyaluronic acid (hyaluronan) is a large glycosaminoglycan (molecular weight 3-4 million Daltons) con...
Synovial fluid contains high concentrations of complement proteins and immunoglobulins; the glucose ...
Joint lubrication occurs through multiple mechanisms: boundary lubrication (surface molecule adhesio...
Lubricin (PRG4/superficial zone protein) is a glycoprotein produced by superficial zone chondrocytes...
Answer the questions to see explanations
Click T (True) or F (False) for each option