Growth Factors and Angiogenesis
A researcher is investigating strategies to enhance fracture healing in a diabetic patient population with known impaired angiogenesis. The team is examining the role of vascular endothelial growth factor (VEGF) in bone repair and considering therapeutic approaches to augment vascularization at the fracture site. Regarding VEGF signaling in bone biology:
Mark each as TRUE or FALSE
VEGF (vascular endothelial growth factor) is the master regulator of angiogenesis; the VEGF family i...
VEGF is essential for both intramembranous and endochondral ossification; during endochondral bone f...
VEGF is not involved in bone biology; it only affects soft tissues; angiogenesis is not important fo...
In fracture healing, VEGF expression peaks during the inflammatory and soft callus phases; hypoxia a...
Clinical implications include: anti-VEGF therapies (bevacizumab for cancer) may impair bone healing ...
Answer the questions to see explanations
Click T (True) or F (False) for each option