Bone Biology
A medical student is preparing for an orthopaedic basic science examination. The examiner asks about the relationship between mechanical loading and bone structure, including the molecular mechanisms that allow bone to sense and respond to mechanical forces. Regarding Wolff's Law and bone adaptation:
Mark each as TRUE or FALSE
Wolff's Law (1892) states that bone adapts its structure to the mechanical demands placed upon it; b...
Mechanotransduction is the process by which bone cells convert mechanical signals into biological re...
Wolff's Law states bone structure is independent of mechanical forces; bone is deposited in areas of...
Mechanical loading decreases osteocyte sclerostin production, reducing inhibition of the Wnt/beta-ca...
Clinical applications include: implant design to minimize stress shielding (load-sharing vs load-bea...
Answer the questions to see explanations
Click T (True) or F (False) for each option