Metabolic Bone Disease
A 68-year-old man is referred after an incidental finding of an elevated serum alkaline phosphatase (ALP) of 450 U/L (normal less than 120) on routine blood tests. He is asymptomatic. His calcium, phosphate, and renal function are normal. A bone scan shows increased uptake in the pelvis, left femur, and skull. Radiographs show coarsened trabecular pattern, cortical thickening, and mixed lytic/sclerotic changes consistent with Paget's disease. Regarding Paget's disease of bone:
Mark each as TRUE or FALSE
Paget's disease is characterized by excessive osteoclast activity followed by disorganized bone form...
Serum alkaline phosphatase (ALP) is the most useful marker for disease activity and monitoring treat...
All patients with Paget's disease require treatment with bisphosphonates regardless of symptoms; tre...
The three phases are lytic (osteoclastic resorption), mixed (resorption and formation), and scleroti...
Common sites include pelvis (70%), femur, tibia, skull, and spine; Paget's disease is monostotic in ...
Answer the questions to see explanations
Click T (True) or F (False) for each option