Orthopaedic Infection Management
A 52-year-old male is undergoing two-stage revision for a periprosthetic joint infection of his total knee arthroplasty. The first-stage procedure includes prosthesis removal and insertion of an antibiotic-loaded cement spacer. Regarding polymethylmethacrylate (PMMA) as a local antibiotic delivery system:
Mark each as TRUE or FALSE
PMMA antibiotic beads and spacers provide high local antibiotic concentrations (up to 100-1000× MIC)...
Antibiotics suitable for PMMA loading must be heat-stable (withstand exothermic polymerization at 60...
PMMA cement beads are biodegradable and should be left in situ permanently to provide ongoing antibi...
Adding more antibiotic increases elution but decreases cement mechanical strength; for load-bearing ...
Antibiotic elution from PMMA follows a biphasic pattern with high initial release over the first 24-...
Answer the questions to see explanations
Click T (True) or F (False) for each option