Musculoskeletal Infections
A basic science viva examiner asks a candidate to explain the pathophysiology of septic arthritis and why urgent treatment is essential. The examiner is particularly interested in the mechanisms by which bacteria cause cartilage destruction and the timeline of irreversible damage. Regarding the pathophysiology of bacterial joint infection:
Mark each as TRUE or FALSE
Bacteria reach the joint primarily via haematogenous spread; the synovial membrane is highly vascula...
Staphylococcus aureus expresses multiple virulence factors including protein A (binds IgG Fc region)...
Cartilage destruction in septic arthritis is caused exclusively by bacterial enzymes; the host infla...
The host inflammatory cascade is a major contributor to cartilage destruction; neutrophils release p...
Irreversible cartilage damage can occur within 24-48 hours of bacterial invasion; elevated intra-art...
Answer the questions to see explanations
Click T (True) or F (False) for each option