Peripheral Neuropathies
A 16-year-old male presents with progressive foot deformity and difficulty walking. He has bilateral high-arched feet, clawed toes, and weakness of ankle dorsiflexion. His gait shows foot drop with high-stepping pattern. Family history reveals his father has similar foot problems. Nerve conduction studies show severely reduced motor conduction velocities (less than 38 m/s). Regarding Hereditary Motor and Sensory Neuropathies (HMSN):
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HMSN (Charcot-Marie-Tooth disease) is the most common inherited peripheral neuropathy affecting 1 in...
The classification divides into demyelinating types (HMSN I/CMT1) with nerve conduction velocity les...
CMT primarily affects the proximal muscles with relative sparing of distal muscles; the most common ...
The cavovarus foot deformity in CMT results from muscle imbalance: peroneus longus overpowers tibial...
The Coleman block test differentiates flexible from fixed hindfoot varus; if hindfoot corrects when ...
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Click T (True) or F (False) for each option