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Paediatrics
intermediate
X-Type

Caffey Disease

Pediatric Bone Conditions

A 10-week-old infant is brought to the emergency department with irritability, poor feeding, and swelling over the left jaw present for 5 days. The parents deny any trauma. Examination reveals a firm, non-fluctuant swelling over the mandible with overlying warmth but no redness. The infant is afebrile. Blood tests show WCC 11.2, ESR 45, CRP 28. Skeletal survey shows periosteal new bone formation along the left mandible with similar findings on bilateral clavicles. Regarding Caffey disease (infantile cortical hyperostosis):

Mark each as TRUE or FALSE

A

The mandible is the most commonly affected bone in Caffey disease, followed by the clavicle and ulna

B

Caffey disease typically presents in infants less than 5 months of age and is extremely rare after 2...

C

The familial form of Caffey disease is inherited in an autosomal dominant pattern with a mutation in...

D

Bone biopsy is essential for diagnosis and shows pathognomonic features that distinguish Caffey dise...

E

The classic radiographic finding is lamellar periosteal new bone formation that produces cortical th...

Answer the questions to see explanations

Click T (True) or F (False) for each option