Skeletal Dysplasias
A 10-year-old boy presents with multiple bony lumps around his knees, ankles, and wrists that have been gradually enlarging over several years. His father and paternal grandmother have similar lesions. Radiographs confirm multiple osteochondromas arising from the metaphyses of long bones. Regarding multiple hereditary exostoses (MHE):
Mark each as TRUE or FALSE
MHE (hereditary multiple exostoses/osteochondromatosis) is an autosomal dominant disorder caused by ...
Osteochondromas in MHE arise from the growth plate and consist of a bony stalk with a cartilage cap ...
Malignant transformation to chondrosarcoma occurs in 25-30% of MHE patients; solitary osteochondroma...
Warning signs of malignant transformation include new or increased pain in a previously painless les...
Indications for surgical excision of osteochondromas include pain, neurovascular compression, functi...
Answer the questions to see explanations
Click T (True) or F (False) for each option