Spinal Oncology
A 32-year-old woman presents with 6 months of progressive lower back pain radiating to her right buttock. She denies bowel or bladder dysfunction. Imaging reveals a lytic expansile lesion in the L3 vertebral body extending into the posterior elements. CT shows characteristic "soap bubble" appearance with no matrix mineralization. MRI demonstrates heterogeneous enhancement with fluid-fluid levels. Biopsy confirms giant cell tumor of bone. Regarding giant cell tumors (GCT) of the spine:
Mark each as TRUE or FALSE
Giant cell tumors of the spine most commonly affect the sacrum (approximately 50%), followed by the ...
Histologically, GCT consists of mononuclear stromal cells (neoplastic component) and multinucleated ...
Spinal GCT has a low recurrence rate after curettage alone regardless of location; sacral GCT should...
Denosumab (anti-RANKL monoclonal antibody) inhibits osteoclast-mediated bone resorption and is used ...
En bloc spondylectomy with wide margins offers the lowest recurrence rate for spinal GCT (approximat...
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Click T (True) or F (False) for each option