Primary Bone Tumors
A 52-year-old man presents with a slowly enlarging mass in his proximal femur that has been present for 2 years with recent onset of dull, aching pain. He has a history of multiple enchondromas. Radiographs show an expansile lytic lesion with stippled calcifications ("rings and arcs") and cortical thickening. MRI shows a lobulated mass with high T2 signal and peripheral enhancement. Biopsy reveals a cartilaginous tumor with moderate cellularity and occasional binucleate cells. Regarding chondrosarcoma:
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Chondrosarcoma is the second most common primary malignant bone tumor in adults (after multiple myel...
Histologic grading is critical for prognosis: Grade 1 (low-grade, low cellularity, minimal atypia - ...
Chondrosarcoma is most common in adolescents; the distal extremities are the typical location; Grade...
Chondrosarcoma is characteristically resistant to chemotherapy and radiation therapy; treatment is p...
Radiographic features include "rings and arcs" calcification pattern (chondroid matrix), endosteal s...
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