Bone Tumors
A 62-year-old man presents with a 4-month history of rapidly progressive hip pain and a palpable mass. He had been told he had a cartilage tumor of the pelvis on imaging 3 years ago but declined treatment. Radiographs show a large destructive lesion with both chondroid matrix (rings and arcs) and an aggressive lytic component without calcification. Biopsy reveals two distinct patterns: low-grade chondrosarcoma and high-grade spindle cell sarcoma resembling osteosarcoma. Regarding dedifferentiated chondrosarcoma:
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Dedifferentiated chondrosarcoma is characterized by a bimorphic pattern consisting of a well-differe...
The typical clinical presentation is rapid onset of pain or acceleration of previously stable sympto...
Dedifferentiated chondrosarcoma has an excellent prognosis similar to low-grade chondrosarcoma; the ...
Biopsy must sample both components to establish the diagnosis; the dedifferentiated component determ...
Poor prognostic factors include pelvic location, large tumor size, incomplete resection margins, and...
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Click T (True) or F (False) for each option