Vascular Bone Tumors
A 35-year-old woman presents with progressive pain in her right proximal tibia. She has had symptoms for 8 months. Radiographs show a well-defined lytic lesion with a geographic pattern and no periosteal reaction. MRI shows an enhancing lesion with surrounding edema. Staging CT reveals two additional similar lesions in the contralateral femur and spine. Biopsy shows epithelioid cells forming vascular channels with intracytoplasmic lumina. Immunohistochemistry is positive for CD31 and ERG. Regarding epithelioid hemangioendothelioma of bone:
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Epithelioid hemangioendothelioma (EHE) is an intermediate-grade vascular tumor classified between he...
Histologically, EHE shows epithelioid endothelial cells with intracytoplasmic vacuoles representing ...
EHE is a benign vascular tumor similar to hemangioma; it only occurs in bone and never in soft tissu...
Radiographically, EHE presents as well-defined lytic lesions with geographic or moth-eaten patterns;...
Treatment depends on extent and location; solitary lesions may be treated with wide resection or cur...
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