Primary Bone Tumors
A 14-year-old boy presents with a 3-month history of progressive right femoral pain and swelling. He reports night pain, fever, and has lost 3kg in weight. Examination reveals a warm, tender mass in the distal thigh. Blood tests show elevated ESR and LDH. Radiographs show a permeative lesion in the femoral diaphysis with periosteal reaction described as "onion skinning." Regarding Ewing sarcoma:
Mark each as TRUE or FALSE
Ewing sarcoma is the second most common primary malignant bone tumor in children after osteosarcoma;...
The characteristic translocation is t(11;22)(q24;q12) creating the EWS-FLI1 fusion gene (found in 85...
Ewing sarcoma is most common in African Americans; peak incidence is over 50 years; it is the most c...
Radiographic features include permeative or moth-eaten destruction, lamellated ("onion skin") perios...
Treatment is multimodal: neoadjuvant chemotherapy (VAC/IE alternating regimen), followed by local co...
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Click T (True) or F (False) for each option