Primary Bone Tumors
A 14-year-old boy presents with a 3-month history of progressive thigh pain and swelling. He has intermittent low-grade fevers. Radiographs show a permeative lytic lesion in the diaphysis of the femur with an "onion skin" periosteal reaction and a large soft tissue mass. Laboratory tests reveal elevated ESR and LDH. Regarding Ewing sarcoma:
Mark each as TRUE or FALSE
Ewing sarcoma is the second most common primary malignant bone tumor in children after osteosarcoma;...
Ewing sarcoma is characterized by the t(11;22) translocation creating the EWS-FLI1 fusion gene found...
Ewing sarcoma is not chemosensitive and chemotherapy has little role in treatment; surgery alone is ...
Radiographic features include permeative or moth-eaten bone destruction, "onion skin" (lamellated) o...
Treatment is multimodal: neoadjuvant chemotherapy followed by local control (surgery and/or radiatio...
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Click T (True) or F (False) for each option