Primary Bone Tumors
A 14-year-old boy presents with 3 months of worsening leg pain and swelling. He has been having intermittent fevers and has lost 4kg. Radiographs show a permeative lytic lesion in the femoral diaphysis with an "onion skin" periosteal reaction. MRI reveals extensive bone marrow involvement and a large soft tissue mass. Laboratory studies show elevated ESR, LDH, and white blood cell count. Biopsy reveals small round blue cells. Regarding Ewing sarcoma:
Mark each as TRUE or FALSE
Ewing sarcoma is the second most common primary malignant bone tumor in children and young adults (a...
The characteristic genetic abnormality is t(11;22)(q24;q12) translocation resulting in EWSR1-FLI1 fu...
Ewing sarcoma is most common in African populations; it typically affects the elderly; the character...
Radiographic features include permeative/moth-eaten lytic pattern, "onion skin" (lamellated) periost...
Treatment involves multimodal therapy: neoadjuvant chemotherapy (VAC/IE regimen - vincristine, doxor...
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Click T (True) or F (False) for each option