Primary Bone Tumors
A 14-year-old boy presents with a 3-month history of progressive left thigh pain and swelling. He reports intermittent fevers and has lost 5kg over this period. Examination reveals a warm, tender mass in the mid-thigh. Blood tests show elevated ESR, CRP, and LDH. Radiographs show a permeative lytic lesion in the femoral diaphysis with extensive periosteal reaction in an "onion-skin" pattern. MRI shows a large soft tissue mass. Biopsy reveals small round blue cells with CD99 positivity. Regarding Ewing sarcoma:
Mark each as TRUE or FALSE
Ewing sarcoma is the second most common primary malignant bone tumor in children and adolescents (af...
The hallmark genetic abnormality is the EWSR1-FLI1 translocation t(11;22)(q24;q12) present in 85% of...
Ewing sarcoma is most common in adults over 40; it typically arises in the epiphysis; the EWSR1 tran...
Radiographic features include permeative or moth-eaten bone destruction in the diaphysis, "onion-ski...
Treatment is multimodal: neoadjuvant chemotherapy (VDC/IE regimen - vincristine, doxorubicin, cyclop...
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Click T (True) or F (False) for each option