Bone Tumors
A 48-year-old woman presents with a 6-month history of progressively worsening thigh pain, worse at night and not completely relieved by NSAIDs. Radiographs show a purely lytic, permeative lesion in the distal femoral metaphysis with cortical destruction and no visible matrix. MRI shows a large soft tissue mass. Biopsy reveals spindle cells arranged in a herringbone pattern, immunohistochemically negative for epithelial markers and S100. Regarding fibrosarcoma of bone:
Mark each as TRUE or FALSE
Primary fibrosarcoma of bone is a rare malignant spindle cell tumor arising from fibroblasts without...
Radiographic appearance is typically a purely lytic, aggressive lesion without matrix mineralization...
Fibrosarcoma is the most common primary bone malignancy; it primarily affects the diaphysis; it prod...
Histologically, fibrosarcoma shows malignant spindle cells arranged in a characteristic "herringbone...
Treatment is wide surgical resection with adequate margins; the role of chemotherapy is debated but ...
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Click T (True) or F (False) for each option