Bone Tumors
A 32-year-old woman presents with 4 months of progressive knee pain and swelling. Radiographs show an eccentric, lytic, expansile lesion in the distal femoral epiphysis extending to the subchondral bone without matrix calcification. There is no periosteal reaction. MRI shows a well-defined lesion with lobular low-to-intermediate T1 and heterogeneous T2 signal. Regarding giant cell tumor (GCT) of bone:
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GCT is a benign but locally aggressive tumor occurring in skeletally mature patients (peak 20-40 yea...
Radiographic features include eccentric, lytic, expansile lesion in the epiphysis with well-defined ...
GCT is a malignant tumor occurring in children; it arises in the metaphysis with sclerotic margins; ...
Histology shows multinucleated osteoclast-like giant cells (RANK-expressing) admixed with mononuclea...
Denosumab (RANKL inhibitor) is used for unresectable, recurrent, or metastatic GCT; it reduces tumor...
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