Bone Tumors
A 32-year-old woman presents with progressive knee pain for 6 months. She has no history of trauma. Radiographs show a lytic lesion in the distal femur extending to the subchondral bone with a "soap bubble" appearance and no matrix. MRI confirms the lesion abuts the articular cartilage. Biopsy shows multinucleated giant cells with round, uniform nuclei identical to the stromal cell nuclei. Regarding giant cell tumor of bone:
Mark each as TRUE or FALSE
Giant cell tumor (GCT) is a benign but locally aggressive bone tumor; it typically occurs in skeleta...
Radiographic features include an eccentric, lytic lesion with well-defined but non-sclerotic margins...
GCT typically occurs in children before skeletal maturity; diaphyseal location is characteristic; sc...
Treatment typically involves extended intralesional curettage (aggressive curettage with high-speed ...
Histologically, GCT shows mononuclear stromal cells (the neoplastic component) and multinucleated gi...
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Click T (True) or F (False) for each option