Bone Tumors
A 32-year-old woman presents with progressive knee pain over 3 months. She has no history of trauma or systemic symptoms. Examination reveals a palpable swelling around the medial femoral condyle. X-rays show an eccentrically located lytic lesion in the distal femoral epiphysis extending to the subchondral bone with well-defined but non-sclerotic margins. MRI confirms the lesion and shows no soft tissue extension. Regarding giant cell tumor of bone:
Mark each as TRUE or FALSE
Giant cell tumor (GCT) is a benign but locally aggressive tumor representing 5% of primary bone tumo...
Radiographic appearance is an eccentrically located, lytic lesion in the epiphysis/metaphysis with w...
GCT most commonly occurs in children before skeletal maturity; it affects the diaphysis; it has scle...
Treatment of Grade 1-2 GCT is extended intralesional curettage with local adjuvants (phenol, liquid ...
Denosumab (RANKL inhibitor) can be used neoadjuvantly to shrink tumor and create a peripheral rim of...
Answer the questions to see explanations
Click T (True) or F (False) for each option