Bone Tumours
A 32-year-old woman presents with a 6-month history of knee pain and swelling. Radiographs show an eccentric lytic lesion in the distal femur extending to the subchondral bone. The lesion is well-defined without sclerotic margins and has a "soap bubble" appearance. There is no periosteal reaction. MRI confirms the lesion extends to within 1mm of the articular cartilage without soft tissue mass. Biopsy confirms giant cell tumour of bone. Regarding giant cell tumour of bone:
Mark each as TRUE or FALSE
Giant cell tumour (GCT) is a locally aggressive benign tumour occurring in skeletally mature patient...
Histologically, GCT contains mononuclear stromal cells (the neoplastic component expressing RANKL) a...
GCT occurs in children before physeal closure; it is typically located in the diaphysis; the giant c...
Treatment for Grade I-II includes intralesional curettage with adjuvants (high-speed burr, phenol, h...
Denosumab (RANKL inhibitor) is used for unresectable or recurrent GCT; it causes tumour ossification...
Answer the questions to see explanations
Click T (True) or F (False) for each option