Bone Tumours
A 28-year-old woman presents with 6 months of progressive knee pain and swelling. The pain is worse with activity and she has noticed a firm mass around her distal femur. Radiographs show an eccentric, lytic lesion in the distal femoral epiphysis extending to the subchondral bone with a narrow zone of transition, no matrix mineralization, and cortical thinning. MRI shows a well-defined lesion with low T1 and heterogeneous T2 signal. There is no periosteal reaction. Regarding giant cell tumour (GCT) of bone:
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GCT is a benign but locally aggressive tumour representing 5-10% of primary bone tumours; it charact...
Radiographic appearance is typically an eccentric, lytic lesion in the epiphysis with a narrow zone ...
GCT occurs most commonly in children before physeal closure; it typically affects the diaphysis; the...
Histologically, GCT contains two cell types: mononuclear stromal cells (neoplastic component with RA...
Treatment options include: extended curettage with adjuvant (phenol, liquid nitrogen, argon beam) an...
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Click T (True) or F (False) for each option