Bone Tumours
A 32-year-old woman presents with knee pain and swelling. Radiographs show an eccentric lytic lesion in the distal femoral epiphysis extending to the subchondral bone with no matrix calcification. MRI confirms a well-defined lesion with soft tissue extension through a cortical breach. Biopsy shows multinucleated giant cells in a mononuclear stromal background. Regarding giant cell tumour of bone:
Mark each as TRUE or FALSE
Giant cell tumour (GCT) is a locally aggressive benign tumour that typically occurs in skeletally ma...
The Campanacci grading system classifies GCT as: Grade I (latent - well-defined margin, intact corte...
GCT typically occurs before skeletal maturity in children; the diaphysis is the most common location...
Standard treatment for Campanacci Grade I-II is extended curettage (high-speed burr) with local adju...
Denosumab (RANKL inhibitor) is used for unresectable, recurrent, or metastatic GCT; it reduces giant...
Answer the questions to see explanations
Click T (True) or F (False) for each option