Hematologic Malignancies
A 68-year-old man presents with progressive back pain and fatigue over 4 months. He has recently developed bilateral rib pain. Laboratory studies show normocytic anemia (Hb 95 g/L), elevated creatinine, and hypercalcemia. Skeletal survey reveals multiple "punched-out" lytic lesions in the skull, spine, and pelvis without sclerotic rim. Regarding multiple myeloma and bone disease:
Mark each as TRUE or FALSE
Multiple myeloma is a plasma cell neoplasm producing monoclonal immunoglobulin (M-protein); it is th...
The CRAB criteria define end-organ damage requiring treatment: Calcium elevation (greater than 2.75 ...
Myeloma produces sclerotic (blastic) bone lesions; bone scan is the imaging modality of choice; elev...
Radiographic features include "punched-out" lytic lesions without sclerotic rim (no osteoblast respo...
Orthopaedic management includes bisphosphonates or denosumab to reduce skeletal events, prophylactic...
Answer the questions to see explanations
Click T (True) or F (False) for each option