Multiple Myeloma
A 68-year-old male presents with progressive lower back pain for 3 months. He reports fatigue and weight loss. Laboratory investigations reveal hemoglobin 95 g/L, creatinine 180 μmol/L, and calcium 3.1 mmol/L. Serum protein electrophoresis demonstrates a monoclonal spike. Plain radiographs of the spine show multiple well-circumscribed lytic lesions without sclerotic margins. Which of the following statements regarding multiple myeloma is MOST accurate?
Mark each as TRUE or FALSE
Multiple myeloma is the most common primary malignancy of bone in adults, arising from clonal prolif...
The CRAB criteria (Calcium elevation, Renal insufficiency, Anemia, Bone lesions) define end-organ da...
Bone scintigraphy is the investigation of choice for detecting myeloma lesions; MRI has low sensitiv...
Bisphosphonates (zoledronic acid) reduce skeletal-related events and should be administered to all p...
Surgical stabilization is indicated for impending or completed pathological fractures; radiotherapy ...
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Click T (True) or F (False) for each option