Non-ossifying Fibroma
A 12-year-old boy presents with mild aching in his right distal thigh after playing football. He has no history of significant trauma. Physical examination is unremarkable. Radiographs show a well-defined, eccentric, cortically-based lytic lesion in the distal femoral metaphysis with a thin sclerotic margin and a "soap bubble" or multiloculated appearance. The lesion measures 3.5cm in length. There is no periosteal reaction, cortical destruction, or soft tissue mass. Regarding this lesion:
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This is a non-ossifying fibroma (NOF), the most common benign fibrous lesion of bone, found incident...
Non-ossifying fibromas and fibrous cortical defects (FCD) represent the same pathological entity on ...
Non-ossifying fibromas have significant malignant potential and require oncological staging; the les...
The natural history is spontaneous resolution with skeletal maturity as the lesion ossifies and is i...
Histologically, NOFs contain spindle-shaped fibroblasts in a storiform (whorled) pattern, scattered ...
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