Primary Bone Tumors
A 15-year-old boy presents with a 2-month history of progressive pain and swelling around his right knee. He reports the pain is worse at night and not relieved by rest. Examination reveals a firm mass in the distal femur with overlying warmth. Radiographs show an aggressive lesion in the distal femoral metaphysis with permeative destruction, periosteal reaction (Codman triangle), and a soft tissue mass with cloudlike ossification. MRI confirms the tumor with skip lesions in the proximal femur. Biopsy reveals high-grade osteoblastic osteosarcoma. Regarding osteosarcoma:
Mark each as TRUE or FALSE
Osteosarcoma is the most common primary malignant bone tumor (excluding myeloma); it has a bimodal a...
The hallmark of osteosarcoma is production of malignant osteoid by tumor cells; radiographic feature...
Osteosarcoma is most common in adults over 50; it arises in the diaphysis; chondrosarcoma is more co...
Staging includes the Enneking system: Stage I (low grade), Stage II (high grade), Stage III (any gra...
Treatment is multimodal: neoadjuvant chemotherapy (MAP - methotrexate, doxorubicin/Adriamycin, cispl...
Answer the questions to see explanations
Click T (True) or F (False) for each option