Bone Tumors
A 55-year-old man presents with 3 months of progressive pain in his right femur that is worse at night. He has no B symptoms (fever, weight loss, night sweats). Examination is unremarkable apart from tenderness over the mid-femoral shaft. Radiographs show a permeative lesion in the femoral diaphysis with periosteal reaction but no soft tissue mass. MRI confirms marrow involvement. Biopsy reveals diffuse large B-cell lymphoma (DLBCL). Staging shows no other sites of involvement. Regarding primary bone lymphoma:
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Primary bone lymphoma (PBL) is defined as lymphoma arising in bone without evidence of systemic dise...
PBL typically presents in adults (median age 45-60) with localized bone pain that may be worse at ni...
PBL is the most common primary bone tumor; it usually presents in children; B symptoms are always pr...
Diagnosis requires biopsy with immunohistochemistry and flow cytometry; staging includes PET-CT, bon...
The 5-year survival for localized PBL treated with combined modality therapy (chemotherapy + radiati...
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Click T (True) or F (False) for each option