Soft Tissue Sarcomas
A 25-year-old man presents with a slowly enlarging mass in his thigh near the knee that has been present for 2 years. It is now painful. Examination reveals a firm, deep 6cm mass. MRI shows a heterogeneous soft tissue mass with areas of hemorrhage and cystic change adjacent to (but not within) the knee joint. Plain radiograph shows focal calcification within the mass. Biopsy reveals a biphasic pattern with epithelial and spindle cell components. Regarding synovial sarcoma:
Mark each as TRUE or FALSE
Synovial sarcoma is a high-grade malignant soft tissue tumor that, despite its name, does NOT arise ...
The pathognomonic translocation t(X;18)(p11;q11) creating the SYT-SSX fusion gene is present in grea...
Synovial sarcoma arises from joint synovium; it only occurs in elderly patients; calcification never...
Imaging features include heterogeneous mass with cystic/necrotic areas, hemorrhage (fluid-fluid leve...
Treatment requires wide surgical resection with negative margins; synovial sarcoma is relatively che...
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Click T (True) or F (False) for each option