Soft Tissue Sarcoma
A 65-year-old man presents with a 3-month history of an enlarging mass in his posterior thigh. Examination reveals a firm, deep 8cm mass. MRI shows a heterogeneous deep soft tissue mass with ill-defined margins. Core needle biopsy shows highly pleomorphic spindle cells with bizarre giant cells, high mitotic rate, and no specific line of differentiation on immunohistochemistry. PET-CT shows no metastatic disease. Regarding undifferentiated pleomorphic sarcoma (UPS):
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UPS (formerly malignant fibrous histiocytoma/MFH) is a high-grade sarcoma diagnosed by exclusion - i...
Histologically, UPS shows marked cellular pleomorphism with spindle cells, bizarre multinucleated gi...
UPS is a low-grade sarcoma with excellent prognosis; it has a specific immunohistochemical marker th...
Staging uses the AJCC system based on tumour size, depth, nodal status, and histologic grade (UPS is...
Treatment requires multidisciplinary approach: wide surgical excision with negative margins (R0) is ...
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